8-OH-DPAT and Male Rat Sexual Behavior: Partial Blockade by Noradrenergic Lesion and Sexual Exhaustion

  title={8-OH-DPAT and Male Rat Sexual Behavior: Partial Blockade by Noradrenergic Lesion and Sexual Exhaustion},
  author={Alonso Fern{\'a}ndez‐Guasti and Gabriela Rodr{\'i}guez-Manzo},
  journal={Pharmacology Biochemistry and Behavior},

Pharmacological and physiological aspects of sexual exhaustion in male rats.

The data suggest that changes in brain androgen receptors account for the inhibition of sexual behavior present during sexual exhaustion and the postejaculatory interval are not mediated by similar mechanisms and that the medial preoptic area does not regulate sexual satiety.

D2-Like Receptors Mediate the Expulsion Phase of Ejaculation Elicited by 8-Hydroxy-2-(di-N-propylamino)tetralin in Rats

It is demonstrated that D2-like receptors mediate the induction by 8-OH-DPAT of rhythmic BS muscle contractions and suggest that i.c.v. delivery of D1-like receptor agonists to anesthetized rats represents a relevant experimental model to study the expulsion phase of ejaculation.

The Role of Brain Opioid Transmission in the Conditioned Ejaculatory Preference of the Male Rat

The results show that opioids are an important substrate of the sexual reward state, and that this state feeds forward to form a conditioned ejaculatory preference (CEP), in which male rats ejaculate preferentially with females bearing or wearing the cue associated with sexual reward.

Unraveling the modulatory actions of serotonin on male rat sexual responses



Effects of a new type of 5-HT receptor agonist on male rat sexual behavior

Yohimbine and serotonergic agonists: Stimulus properties and receptor binding

Comparing the discriminative stimulus properties of yohimbine and purported agonists at the serotonin (5‐HT)1A receptor suggests that clonidine may function as a partial agonist, and argues against stimulus control mediated solely by a 5‐HT1A‐based mechanism.

Yohimbine as a serotonergic agent: evidence from receptor binding and drug discrimination.

  • J. C. WinterR. Rabin
  • Biology, Psychology
    The Journal of pharmacology and experimental therapeutics
  • 1992
The present data suggest that rats trained with yohimbine as a discriminative stimulus generalize to drugs with minimal affinity for the alpha 2 adrenoceptor but with high affinity for 5-HT1A receptors.