8-Hydroxyquinoline inhibits iNOS expression and nitric oxide production by down-regulating LPS-induced activity of NF-kappaB and C/EBPbeta in Raw 264.7 cells.

@article{Kim20058HydroxyquinolineII,
  title={8-Hydroxyquinoline inhibits iNOS expression and nitric oxide production by down-regulating LPS-induced activity of NF-kappaB and C/EBPbeta in Raw 264.7 cells.},
  author={Youngho Kim and Kyung Jin Woo and Jun Hee Lim and Shin Hyoung Kim and Tae Jin Lee and Eun Mi Jung and Jin-Man Lee and Jong-Wook Park and Taeg Kyu Kwon},
  journal={Biochemical and biophysical research communications},
  year={2005},
  volume={329 2},
  pages={591-7}
}
In activated macrophage, large amounts of nitric oxide (NO) are generated by inducible nitric oxide synthase (iNOS), resulting in acute or chronic inflammatory disorders. In Raw 264.7 cells stimulated with lipopolysaccharide (LPS) to mimic inflammation, 8-hydroxyquinoline (8HQ) inhibited the LPS-induced expression of both iNOS protein and mRNA in a parallel dose-dependent manner. 8HQ did not enhance the degradation of iNOS mRNA. To investigate the mechanism by which 8HQ inhibits iNOS gene… CONTINUE READING

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