8-Hydroxydeoxyguanosine levels in human leukocyte and urine according to exposure to organophosphorus pesticides and paraoxonase 1 genotype.

@article{Lee20078HydroxydeoxyguanosineLI,
  title={8-Hydroxydeoxyguanosine levels in human leukocyte and urine according to exposure to organophosphorus pesticides and paraoxonase 1 genotype.},
  author={Chul-Ho Lee and Michihiro Kamijima and Heon Kyu Kim and Eiji Shibata and Jun Ueyama and Takayoshi Suzuki and K. Takagi and Isao Saito and Masahiro Gotoh and Hatsuki Hibi and Hisao Naito and Tamie Nakajima},
  journal={International archives of occupational and environmental health},
  year={2007},
  volume={80 3},
  pages={217-27}
}
OBJECTIVE In order to investigate a role of paraoxonase 1 (PON1) polymorphism in organophosphorus (OP)-induced 8-hydroxydeoxyguanosine (8-OHdG) levels, urinary metabolites of OP, PON1 genotypes, and 8-OHdG levels in leukocyte and urine were measured in OP indoor insecticide sprayers and controls in summer and winter. METHODS The study population contained 18 male sprayers and age-matched 18 male controls. Sprayers were primarily exposed to OP insecticides (mainly fenitrothion, dichlorvos… CONTINUE READING

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