8-Carboxamidocyclazocine: a long-acting, novel benzomorphan.

@article{Bidlack20028CarboxamidocyclazocineAL,
  title={8-Carboxamidocyclazocine: a long-acting, novel benzomorphan.},
  author={Jean M. Bidlack and Dana J. Cohen and Jay P. McLaughlin and Rongliang Lou and Y Ye and Mark P. Wentland},
  journal={The Journal of pharmacology and experimental therapeutics},
  year={2002},
  volume={302 1},
  pages={
          374-80
        }
}
To obtain benzomorphans with a longer duration of action that may be potential therapeutics for treating cocaine abuse, 8-carboxamidocyclazocine was synthesized. The pharmacological properties of 8-carboxamidocyclazocine were compared with the parent compound cyclazocine. Changing the 8-hydroxyl group on cyclazocine to an 8-carboxamido group resulted in only a 2-fold decrease in the affinity of the compound for the kappa-receptor, and no change in the affinity for the mu-opioid receptor, with… 

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