8-(3-Chlorostyryl)caffeine may attenuate MPTP neurotoxicity through dual actions of monoamine oxidase inhibition and A2A receptor antagonism.

@article{Chen200283ChlorostyrylcaffeineMA,
  title={8-(3-Chlorostyryl)caffeine may attenuate MPTP neurotoxicity through dual actions of monoamine oxidase inhibition and A2A receptor antagonism.},
  author={Jiang-fan Chen and Salome Steyn and Roland G. W. Staal and Jacobus P Petzer and Kui Xu and Cornelis J van der Schyf and Kay P Castagnoli and Patricia K. Sonsalla and Neal Castagnoli and Michael A. Schwarzschild},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 39},
  pages={36040-4}
}
Caffeine and more specific antagonists of the adenosine A(2A) receptor recently have been found to be neuroprotective in the MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) model of Parkinson's disease. Here we show that 8-(3-chlorostyryl)caffeine (CSC), a specific A(2A) antagonist closely related to caffeine, also attenuates MPTP-induced neurotoxicity. Because the neurotoxicity of MPTP relies on its oxidative metabolism to the mitochondrial toxin MPP(+), we investigated the actions of CSC… CONTINUE READING