7alpha-Hydroxypregnenolone acts as a neuronal activator to stimulate locomotor activity of breeding newts by means of the dopaminergic system.

@article{Matsunaga20047alphaHydroxypregnenoloneAA,
  title={7alpha-Hydroxypregnenolone acts as a neuronal activator to stimulate locomotor activity of breeding newts by means of the dopaminergic system.},
  author={Masahiro Matsunaga and Kazuyoshi Ukena and Etienne Emile Baulieu and Kazuyoshi Tsutsui},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2004},
  volume={101 49},
  pages={17282-7}
}
It is becoming clear that steroids can be synthesized de novo by the brain and other nervous systems. Such steroids are called neurosteroids, and de novo neurosteroidogenesis from cholesterol is a conserved property of vertebrate brains. In this study, we show that the newt brain actively produces 7alpha-hydroxypregnenolone, a previously undescribed amphibian neurosteroid that stimulates locomotor activity. 7alpha-hydroxypregnenolone was identified as a most abundant amphibian neurosteroid in… CONTINUE READING
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