7SK snRNA-mediated, gene-specific cooperativity of HMGA1 and P-TEFb.

Abstract

7SK small-nuclear RNA has been shown to negatively regulate P-TEFb transcription elongation on the one hand and control HMGA1 transcription initiation and chromatin remodeling on the other. The non-coding 7SK RNA thereby directly interacts with both factors through different regions. While the loop 2 of the RNA specifically binds to the first HMGA1 A/T hook… (More)
DOI: 10.4161/rna.8.6.17015

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