74. Decreased dorsolateral prefrontal n-acetyl aspartate in bipolar disorder

  title={74. Decreased dorsolateral prefrontal n-acetyl aspartate in bipolar disorder},
  author={Mirene E Winsberg and N Sachs and David L. Tate and M Dunai and Terence A. Ketter},
  journal={Biological Psychiatry},
BACKGROUND N-acetyl aspartate (NAA) is an amino acid present in high concentrations in neurons and is thus a putative neuronal marker. In vivo proton magnetic resonance spectroscopy ((1)H MRS) studies have shown lower NAA concentrations in patients with various neurodegenerative disorders, suggesting decreased neuronal number, size, or function. Dorsolateral prefrontal (DLPF) NAA has not been extensively assessed in bipolar disorder patients, but it could be decreased in view of consistent… CONTINUE READING
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