Corpus ID: 96816081

714, and 11 C-PK11195 in a Rat Model of Acute Neuroinflammation

@inproceedings{Chauveau2009714A1,
  title={714, and 11 C-PK11195 in a Rat Model of Acute Neuroinflammation},
  author={Fabien Chauveau and Nadja van Camp and Bertrand Kuhnast and Annelaure Damont and Michelle L. James and Michael Kassiou and Bertrand Tavitian},
  year={2009}
}
  • Fabien Chauveau, Nadja van Camp, +4 authors Bertrand Tavitian
  • Published 2009
  • Chemistry
  • Overexpression of the translocator protein, TSPO (18 kDa), formerly known as the peripheral benzodiazepine receptor, is a hallmark of activation of cells of monocytic lineage (microglia and macrophages) during neuroinflammation. Radiolabeling of TSPO ligands enables the detection of neuroinflammatory lesions by PET. Two new radioligands, 11C-labeled N,N-diethyl-2-[2-(4methoxyphenyl)-5,7-dimethylpyrazolo[1,5-a]pyrimidin-3-yl] acetamide (DPA-713) and 18F-labeled N,N-diethyl-2-(2-(4-(2fluoroethoxy… CONTINUE READING

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