70S-scanning initiation is a novel and frequent initiation mode of ribosomal translation in bacteria.

@article{Yamamoto201670SscanningII,
  title={70S-scanning initiation is a novel and frequent initiation mode of ribosomal translation in bacteria.},
  author={Hiroshi Yamamoto and Daniela Wittek and Romi Das Gupta and Bo Qin and Takuya Ueda and Roland Krause and Kaori Yamamoto and Renate Albrecht and Markus Pech and Knud H. Nierhaus},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2016},
  volume={113 9},
  pages={E1180-9}
}
According to the standard model of bacterial translation initiation, the small ribosomal 30S subunit binds to the initiation site of an mRNA with the help of three initiation factors (IF1-IF3). Here, we describe a novel type of initiation termed "70S-scanning initiation," where the 70S ribosome does not necessarily dissociate after translation of a cistron, but rather scans to the initiation site of the downstream cistron. We detailed the mechanism of 70S-scanning initiation by designing unique… CONTINUE READING
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