7-nitroindazole reduces nitrite concentration in rat brain after intrahippocampal kainate-induced seizure.

@article{Radenovi20037nitroindazoleRN,
  title={7-nitroindazole reduces nitrite concentration in rat brain after intrahippocampal kainate-induced seizure.},
  author={Lidija Radenovi{\'c} and Ivana Vasiljevi{\'c} and Vesna Selakovi{\'c} and Marina Jovanovi{\'c}},
  journal={Comparative biochemistry and physiology. Toxicology & pharmacology : CBP},
  year={2003},
  volume={135 4},
  pages={443-50}
}
Kainic acid is an endogenous excitotoxin acting on glutamate receptors, that leads to neurotoxic damage resembling the alterations observed in some neurological disorders. Stimulation of glutamate receptors induces neuronal nitric oxide (NO) release, which in turn modulates glutamate transmission. NO may be a key mediator of excitotoxic neuronal injury in the central nervous system. We investigated the effects of 7-nitroindazole, a selective neuronal nitric oxide synthase inhibitor in vivo, on… CONTINUE READING