7-ketocholesterol incorporation into sphingolipid/cholesterol-enriched (lipid raft) domains is impaired by vitamin E: a specific role for alpha-tocopherol with consequences on cell death.

@article{Royer20097ketocholesterolII,
  title={7-ketocholesterol incorporation into sphingolipid/cholesterol-enriched (lipid raft) domains is impaired by vitamin E: a specific role for alpha-tocopherol with consequences on cell death.},
  author={M Royer and St{\'e}phanie Lemaire-Ewing and Catherine M Desrumaux and Serge Monier and Jean-Paul Pais de Barros and Anne Athias and D. Neel and Laurent Lagrost},
  journal={The Journal of biological chemistry},
  year={2009},
  volume={284 23},
  pages={15826-34}
}
Cholesterol oxides, in particular 7-ketocholesterol, are proatherogenic compounds that induce cell death in the vascular wall when localized in lipid raft domains of the cell membrane. Deleterious effects of 7-ketocholesterol can be prevented by vitamin E, but the molecular mechanism involved is unclear. In this study, unlike gamma-tocopherol, the alpha-tocopherol vitamin E form was found to prevent 7-ketocholesterol-mediated apoptosis of A7R5 smooth muscle cells. To be operative, alpha… CONTINUE READING

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Tocopherol and 7-Ketocholesterol in Lipid Rafts 15834 JOURNAL OF BIOLOGICAL CHEMISTRY

M. G. Traber, J. Atkinson
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