7-hydroxy-3-(4-hydroxybenzyl)chroman and broussonin b: neurotrophic compounds, isolated from Anemarrhena asphodeloides BUNGE, function as proteasome inhibitors.

@article{Tsukamoto20057hydroxy34hydroxybenzylchromanAB,
  title={7-hydroxy-3-(4-hydroxybenzyl)chroman and broussonin b: neurotrophic compounds, isolated from Anemarrhena asphodeloides BUNGE, function as proteasome inhibitors.},
  author={Sachiko Tsukamoto and Takeshi Wakana and Keiichirou Koimaru and Takushi Yoshida and Mako Sato and Tomihisa Ohta},
  journal={Biological & pharmaceutical bulletin},
  year={2005},
  volume={28 9},
  pages={1798-800}
}
The extract of Anemarrhenae Rhizoma (rhizomes of Anemarrhena asphodeloides BUNGE) showed neurotrophic activity toward rat pheochromocytoma (PC-12) cells. Bioassay-guided purification afforded four compounds, 2,6,4'-trihydroxy-4-methoxybenzophenone (1), 7-hydroxy-3-(4-hydroxybenzyl)chroman (2), broussonin B (3), and cis-hinokiresinol (4). Compounds 1-3 induced neurite outgrowth in PC-12 cells at concentration of 50 microg/ml, while 4 was less active. In addition, compounds 2-4 showed moderate… CONTINUE READING

From This Paper

Figures, tables, and topics from this paper.

Citations

Publications citing this paper.
Showing 1-7 of 7 extracted citations

The genus Anemarrhena Bunge: A review on ethnopharmacology, phytochemistry and pharmacology.

Journal of ethnopharmacology • 2014
View 3 Excerpts
Highly Influenced

References

Publications referenced by this paper.

Isolated from Anemarrhena asphodeloides Table 1. Effects of Compounds Isolated from A. asphodeloides on Neurite-Outgrowth in PC-12 Cells Neurite-outgrowth

S. Tsukamoto, Y. Yamashita, T. Yoshida, T. Ohta, Mar
NGF • 2005

Similar Papers

Loading similar papers…