7-fluoroindole as an antivirulence compound against Pseudomonas aeruginosa.

  title={7-fluoroindole as an antivirulence compound against Pseudomonas aeruginosa.},
  author={Jin-Hyung Lee and Yong-Guy Kim and Moo Hwan Cho and Jung-Ae Kim and Jintae Lee},
  journal={FEMS microbiology letters},
  volume={329 1},
The emergence of antibiotic resistance has necessitated new therapeutic approaches for combating persistent bacterial infection. An alternative approach is regulation of bacterial virulence instead of growth suppression, which can readily lead to drug resistance. The virulence of the opportunistic human pathogen Pseudomonas aeruginosa depends on a large number of extracellular factors and biofilm formation. Thirty-one natural and synthetic indole derivatives were screened. 7-fluoroindole (7FI… CONTINUE READING
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