7-Oxo-cholesterol potentiates pro-inflammatory signaling in human M1 and M2 macrophages.

  title={7-Oxo-cholesterol potentiates pro-inflammatory signaling in human M1 and M2 macrophages.},
  author={Brigitta Buttari and Luca Segoni and Elisabetta Profumo and Daniela Agnese D'Arcangelo and Stefania Rossi and Francesco Facchiano and Rita Businaro and Luigi Iuliano and Rachele Rigan{\`o}},
  journal={Biochemical pharmacology},
  volume={86 1},
Macrophages, the major cellular components of atherosclerotic plaques, consist of two main subsets: the pro-inflammatory, M1 or classically activated macrophages, and the anti-inflammatory, M2 or alternatively activated macrophages. The molecular and cellular mechanisms that orchestrate the macrophage polarization and activation that may play a role in plaque progression and stability are poorly understood. Recent studies suggest that oxysterols, oxidative stress-mediated cholesterol oxidation… CONTINUE READING


Publications citing this paper.
Showing 1-9 of 9 extracted citations


Publications referenced by this paper.
Showing 1-10 of 49 references

Tolerance and M2 (alternative) macrophage polarization are related processes orchestrated by p50 nuclear factor kappaB.

Proceedings of the National Academy of Sciences of the United States of America • 2009
View 12 Excerpts
Highly Influenced

Oxysterol-induced up-regulation of MCP-1 expression and synthesis in macrophage cells.

Free radical biology & medicine • 2005
View 11 Excerpts
Highly Influenced

Activated hepatic stellate cells mediate the differentiation of macrophages.

Hepatology research : the official journal of the Japan Society of Hepatology • 2013

Differing association of macrophage subsets with atherosclerotic plaque stability.

International angiology : a journal of the International Union of Angiology • 2013

Similar Papers

Loading similar papers…