7-Oxo-cholesterol potentiates pro-inflammatory signaling in human M1 and M2 macrophages.

@article{Buttari20137OxocholesterolPP,
  title={7-Oxo-cholesterol potentiates pro-inflammatory signaling in human M1 and M2 macrophages.},
  author={Brigitta Buttari and Luca Segoni and Elisabetta Profumo and Daniela Agnese D'Arcangelo and Stefania Rossi and Francesco Facchiano and Rita Businaro and Luigi Iuliano and Rachele Rigan{\`o}},
  journal={Biochemical pharmacology},
  year={2013},
  volume={86 1},
  pages={130-7}
}
Macrophages, the major cellular components of atherosclerotic plaques, consist of two main subsets: the pro-inflammatory, M1 or classically activated macrophages, and the anti-inflammatory, M2 or alternatively activated macrophages. The molecular and cellular mechanisms that orchestrate the macrophage polarization and activation that may play a role in plaque progression and stability are poorly understood. Recent studies suggest that oxysterols, oxidative stress-mediated cholesterol oxidation… CONTINUE READING

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