7-OH-DPAT and PD 128907 Selectively Activate the D3 Dopamine Receptor in a Novel Environment

  title={7-OH-DPAT and PD 128907 Selectively Activate the D3 Dopamine Receptor in a Novel Environment},
  author={Laurel M. Pritchard and Aaron D. Logue and Scott M. Hayes and Jeffrey Welge and Ming Xu and Jianhua Zhang and S. Paul Berger and Neil M. Richtand},
The D3 dopamine receptor is expressed primarily in limbic brain areas, and appears to play an inhibitory role in rodent locomotor behavior. Evidence suggests a potential role for the D3 receptor in the pathology of neuropsychiatric disease. Progress in elucidating D3 receptor function has been hampered, however, by a lack of well-characterized, selective ligands and by conflicting information regarding the behavioral phenotype of D3 receptor knockout mice. Here, we describe studies evaluating… 
Role of cerebellar dopamine D3 receptors in modulating exploratory locomotion and cataleptogenicity in rats
The role of central dopamine D3 receptors in drug addiction: a review of pharmacological evidence
Differential effects of dopamine D1 and D2/3 receptor antagonism on motor responses
The results suggest that zebrafish, a cheaper and simpler model organism compared to the rat and the mouse, may be an efficient translationally relevant tool for the analysis of the psychopharmacology of receptors of the vertebrate dopaminergic system.
The role of dopamine D3 compared with D2 receptors in the control of locomotor activity: a combined behavioural and neurochemical analysis with novel, selective antagonists in rats
The facilitatory influence of a “high” dose of PD128,907 upon locomotion is mediated by postsynaptic D2 receptors and, possibly, countered by their D3 counterparts, while selective blockade of D2 but not of D3 receptors alone suppresses motor function.
Dopamine Receptors and Behavior: From Psychopharmacology to Mutant Models
This chapter seeks to summarize the classical psychopharmacology of dopamine receptor subtype function, provide an overview of recent findings in dopamine receptors subtype knockouts across several domains of behavior, and interpret new insights in the context of the limitations of these techniques and prior knowledge of the regulation of behavior by dopamine receptors.
Effects of dopamine D3 receptor antagonists on spontaneous and agonist-reduced motor activity in NMRI mice and Wistar rats: comparative study with nafadotride, U 99194A and SB 277011
Comparing the effects of dopamine D3 antagonists with different levels of selectivity over D2 receptors on motor activity as well as on agonist-induced hypoactivity, in mice and rats found significant species differences and movement-type differences were observed.


In vivo occupancy of D2 dopamine receptors by 7-OH-DPAT.
Protection against inactivation by EEDQ was used as a measure of in vivo occupancy of D2 receptors by behaviorally relevant doses of 7-OH-DPAT and ex vivo [3H]spiperone binding was determined in striatal membranes.
Selective D3 receptor agonist effects of (+)-PD 128907 on dialysate dopamine at low doses
Dopamine D3 receptor mutant and wild‐type mice exhibit identical responses to putative D3 receptor‐selective agonists and antagonists
It is proposed that D3 receptors are unlikely to be involved in motor activity and hypothermic responses and that the putative D3 ligands that have been used to reach conclusions regarding the functional roles of D3 receptor lack the necessary in vivo selectivity to support such conclusions.
Neurochemical and functional characterization of the preferentially selective dopamine D3 agonist PD 128907.
Findings indicating that PD 128907 shows a preference for DA D3 over D2L and D4.2 receptors indicates that its action at low doses may be due to interaction with D3 receptors and at higher doses, with both D2 and D 3 receptors.
Dopamine D3 Receptor Mutant Mice Exhibit Increased Behavioral Sensitivity to Concurrent Stimulation of D1 and D2 Receptors
A targeted mutation of the D3 dopamine receptor gene is associated with hyperactivity in mice.
  • D. Accili, C. Fishburn, S. Fuchs
  • Biology, Psychology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1996
The authors' findings indicate that D3 receptors play an inhibitory role in the control of certain behaviors, and this mutation is associated with hyperactivity in an exploratory test.
The dopamine D3 receptor antagonist nafadotride inhibits development of locomotor sensitization to amphetamine
Decreased binding of dopamine D3 receptors in limbic subregions after neonatal bilateral lesion of rat hippocampus
It is suggested that behavioral changes in the neonatally hippocampal-lesioned rats may be mediated by altered D3 receptor levels.