7-OH-DPAT and PD 128907 Selectively Activate the D3 Dopamine Receptor in a Novel Environment

@article{Pritchard20037OHDPATAP,
  title={7-OH-DPAT and PD 128907 Selectively Activate the D3 Dopamine Receptor in a Novel Environment},
  author={Laurel M. Pritchard and Aaron D. Logue and Scott M. Hayes and Jeffrey Welge and Ming Xu and Jianhua Zhang and S. Paul Berger and Neil M. Richtand},
  journal={Neuropsychopharmacology},
  year={2003},
  volume={28},
  pages={100-107}
}
The D3 dopamine receptor is expressed primarily in limbic brain areas, and appears to play an inhibitory role in rodent locomotor behavior. Evidence suggests a potential role for the D3 receptor in the pathology of neuropsychiatric disease. Progress in elucidating D3 receptor function has been hampered, however, by a lack of well-characterized, selective ligands and by conflicting information regarding the behavioral phenotype of D3 receptor knockout mice. Here, we describe studies evaluating… 
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69 Citations
Highly Influential Citations
4
Background Citations
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Methods Citations
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Results Citations
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69 Citations

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TLDR
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TLDR
Comparing the effects of dopamine D3 antagonists with different levels of selectivity over D2 receptors on motor activity as well as on agonist-induced hypoactivity, in mice and rats found significant species differences and movement-type differences were observed.
In vitro and in vivo characterization of the agonist-dependent D3 dopamine receptor tolerance property
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