7-Nitroindazole down-regulates dopamine/DARPP-32 signaling in neostriatal neurons in a rat model of Parkinson's disease.

@article{Yuste20127NitroindazoleDD,
  title={7-Nitroindazole down-regulates dopamine/DARPP-32 signaling in neostriatal neurons in a rat model of Parkinson's disease.},
  author={Jose Yuste and Marcela Berm{\'u}dez Echeverry and Francisco Ros-Bernal and Aurora G{\'o}mez and Carmen Mar{\'i}a Ros and Carmen Mar{\'i}a Campuzano and Emiliano Fern{\'a}ndez-Villalba and Mar{\'i}a Trinidad Herrero},
  journal={Neuropharmacology},
  year={2012},
  volume={63 7},
  pages={1258-67}
}
Neuronal nitric oxide synthase (nNOS) is involved in the regulation of diverse intracellular messenger systems in the brain. Nitric Oxide (NO) contributes to inducing signaling cascades that involve a complex pattern of phosphorylation of DARPP-32 (in Thr-34), which controls the phosphoproteins involved in neuronal activation. However, the role of NO in the pathophysiology of Parkinson's disease (PD) and its effect in striatal neurons have been scarcely explored. In the present work, we… CONTINUE READING
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