7-Keto hybrid steroidal esters of nitrogen mustard: cytogenetic and antineoplastic effects

@article{Karayianni20027KetoHS,
  title={7-Keto hybrid steroidal esters of nitrogen mustard: cytogenetic and antineoplastic effects},
  author={Venetia Karayianni and A. Papageorgiou and E. Mioglou and Z. Iakovidou and D. Mourelatos and M. Fousteris and A. Koutsourea and E. Arsenou and S. Nikolaropoulos},
  journal={Anti-Cancer Drugs},
  year={2002},
  volume={13},
  pages={637-643}
}
Four newly synthesized antitumor steroidal compounds were compared, on a molar basis, regarding their ability to induce sister chromatid exchanges (SCEs) and cell division delays. The concept of designing and developing these compounds (1–4) is to enhance the anticancer activity of esteric steroidal derivatives of nitrogen mustard by introduction of a keto group at the 7-position of the D5 steroidal skeleton, and a double bond between positions 6 and 7 of the B ring of the steroidal nucleus. In… Expand
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