7 Final Report on the Safety Assessment of Sodium Lauryl Sulfate and Ammonium Lauryl Sulfate

  title={7 Final Report on the Safety Assessment of Sodium Lauryl Sulfate and Ammonium Lauryl Sulfate},
  journal={International Journal of Toxicology},
  pages={127 - 181}
  • Published 1 December 1983
  • Chemistry
  • International Journal of Toxicology
Sodium and Ammonium Lauryl Sulfate are anionic surfactants used in cosmetics as cleansing agents. In absorption, metabolism, and excretion studies, Sodium Lauryl Sulfate had a degenerative effect on the cell membranes because of its protein denaturing properties. Low levels of skin penetration may occur at high use concentration. Sodium Lauryl Sulfate had an LD50 of 0.8 to 1.10 g/kg in rats. A formulation containing 15% Ammonium Lauryl Sulfate caused depression, labored breathing, diarrhea, and… 

1: Final Report on the Safety Assessment of Sodium Lauryl Sulfoacetate

  • Chemistry, Medicine
  • 1987
It is concluded that Sodium Lauryl Sulfoacetate is safe for use in cosmetic products in the present practices of use and concentration.

Final Report on the Safety Assessment of Sodium Cetearyl Sulfate and Related Alkyl Sulfates as Used in Cosmetics

Sodium cetearyl sulfate and related alkyl sulfates are safe in the practices of use and concentration described in the safety assessment, and these ingredients are surfactants used at concentrations from 0.1% to 29%.

Effects of 0.5% and 2.0% Sodium Lauryl Sulfate in Male CD-1 Mice From a 3-Month Oral Gavage Toxicity Study

Sponsors utilizing formulations containing SLS in toxicity studies in CD-1 mice should exclude gastroesophageal reflux as a confounding factor in studies with morbidity or mortality associated with respiratory distress or evidence of aerophagia.

The Biocompatibility of Sodium Lauryl Sulphate on Developing Zebrafish Embryos

The findings showed LPO increased significantly in both low SLS and high SLS exposed zebrafish embryos, indicating increased oxidative stress in the pathophysiology of various diseases.

Human and Environmental Toxicity of Sodium Lauryl Sulfate (SLS): Evidence for Safe Use in Household Cleaning Products

This review demonstrates how scientific works can be misinterpreted and used in a manner that was not intended by the authors, while simultaneously providing insight into the true environmental health impact of SLS.

The effect of the cytotoxicity of sodium lauryl sulfate containing toothpaste on HaCaT and NIH-3T3 cells

SLS had toxicity of the human keratinocyte cells and mouse fibroblast cells and this study will provide the basic data for the development of proper SLS concentration in dentifrice.

Toxic impacts induced by Sodium lauryl sulfate in Mytilus galloprovincialis.

The History of Surfactants and Review of Their Allergic and Irritant Properties

The most frequently used surfactants, as well as their correlation between ACD and ICD, will be reviewed.

Preparation and Characterization of Solid Dispersions Composed of Curcumin, Hydroxypropyl Cellulose and/or Sodium Dodecyl Sulfate by Grinding with Vibrational Ball Milling

Amorphous curcumin (CUR) and amorphous solid dispersions (SDs) consisting of CUR, hydroxypropyl cellulose (HPC) and/or sodium dodecyl sulfate (SDS) were developed using vibrational ball milling to improve drug solubility.

Safety Assessment of Ethanolamine and Ethanolamine Salts as Used in Cosmetics

The Panel concluded that these ingredients are safe in the present practices of use and concentrations (rinse-off products only) when formulated to be nonirritating, and these ingredients should not be used in cosmetic products in which N-nitroso compounds may be formed.



Toxicologic studies on sodium lauryl glyceryl ether sulfonate and sodium lauryl trioxyethylene sulfate.

The acute and chronic toxicity of sodium lauryl glyceryl ether sulfonate and sodium lauryl trioxyethylene sulfate have been studied in rats, and skin tumorigenicity has been investigated in mice.

Factors which determine the skin irritation potential of soaps and detergents

a series of pure SURFACTANTS. Effects of these compounds upon the STRATUM CORNEUM have been studied by means of KERATIN denaturation and the extraction of PROTEINS and AMINO ACIDS. It was found that

Sodium lauryl sulfate irritant patch tests: Degree of inflammation at various times

Fading of irritant reactions by 48 or 72 h may not reliably distinguish irritant from allergic patch test, reactions, and suggests that inflammatory responses in skin for at least certain irritants like sodium lauryl sulfate do slowly decrease in intensity after 48 h.

Chronic oral toxicities of surface-active agents.

  • O. FitzhughA. A. Nelson
  • Chemistry
    Journal of the American Pharmaceutical Association. American Pharmaceutical Association
  • 1948
The results of the chronic study indicate a high degree of toxicity for alkyl dimethyl benzyl ammonium chloride, which was toxic to rats at a concentration of 0.063% or more in the diet.

The determination of the irritancy potential of surfactants using various methods of assessment.

Results from the mouse upper respiratory tract and mouse writhing tests indicated that SLES, MC2M and MMHT were the least irritating and SLS, ALS and TEALS were the most irritating.

The effect of detergents on swelling of stratum corneum

It is concluded that protein denaturants do not cause stratum corneum swelling, but that swelling is due to a reversible conformation change resulting from cooperative binding of the detergent.

Interaction of keratinous substrates with sodium lauryl sulfate..

Synopsis Use was made of radiotagged SODIUM LAURYL SULFATE (SLS) to determine its sorption by skin and hair. In the initial stages uptake is linear in square root of time, indicative of a diffusion

Effect of some irritants on human epidermal mitosis

It is suggested that it might provide a useful model for situations of increased epidermal cell turnover such as psoriasis and it is also noted that there was apparently no direct relationship between gross inflammation and the mitotic response.