7-Deaza-6-benzylthioinosine analogues as subversive substrate of Toxoplasma gondii adenosine kinase: activities and selective toxicities.

@article{Safarjalani20087Deaza6benzylthioinosineAA,
  title={7-Deaza-6-benzylthioinosine analogues as subversive substrate of Toxoplasma gondii adenosine kinase: activities and selective toxicities.},
  author={Omar N Al Safarjalani and Reem H. Rais and Young Ah Kim and Chung K Chu and Fardos N. M. Naguib and Mahmoud H El Kouni},
  journal={Biochemical pharmacology},
  year={2008},
  volume={76 8},
  pages={958-66}
}
Toxoplasma gondii adenosine kinase (EC.2.7.1.20) is the major route of adenosine metabolism in this parasite. The enzyme is significantly more active than any other enzyme of the purine salvage in T. gondii and has been established as a potential chemotherapeutic target for the treatment of toxoplasmosis. Certain 6-benzylthioinosines act as subversive substrates of T. gondii, but not human, adenosine kinase. Therefore, these compounds are preferentially metabolized to their respective… CONTINUE READING

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