7-Chlorokynurenic acid is a selective antagonist at the glycine modulatory site of the N-methyl-D-aspartate receptor complex.

@article{Kemp19887ChlorokynurenicAI,
  title={7-Chlorokynurenic acid is a selective antagonist at the glycine modulatory site of the N-methyl-D-aspartate receptor complex.},
  author={John A. Kemp and Alan C. Foster and Paul D. Leeson and Tony Priestley and R. Tridgett and Leslie Lars Iversen and George Woodruff},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={1988},
  volume={85 17},
  pages={6547-50}
}
Glycine markedly potentiates N-methyl-D-aspartate (N-Me-D-Asp) responses in mammalian neurons by an action at a modulatory site on the N-Me-D-Asp receptor-ionophore complex. Here we present evidence that 7-chlorokynurenic acid (7-Cl KYNA) inhibits N-Me-D-Asp responses by a selective antagonism of glycine at this modulatory site. In rat cortical slices 7-Cl KYNA (10-100 microM) noncompetitively inhibited N-Me-D-Asp responses, and this effect could be reversed by the addition of glycine (100… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 89 extracted citations

Sigma , PCP , and NMDA Receptors 133

View 4 Excerpts
Highly Influenced

Transporters buffer synaptically released glutamate on a submillisecond time scale.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 1997
View 2 Excerpts
Highly Influenced

Modulation of glycine affinity for NMDA receptors by extracellular Ca2+ in trigeminal neurons.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 1994
View 4 Excerpts
Highly Influenced

Dual effect of glycine on NMDA-induced neurotoxicity in rat cortical cultures.

The Journal of neuroscience : the official journal of the Society for Neuroscience • 1990
View 5 Excerpts
Highly Influenced

Similar Papers

Loading similar papers…