7-Azidomethoxy-coumarins as profluorophores for templated nucleic acid detection.

  title={7-Azidomethoxy-coumarins as profluorophores for templated nucleic acid detection.},
  author={Raphael M Franzini and Eric T. Kool},
  journal={Chembiochem : a European journal of chemical biology},
  volume={9 18},
Templated nucleic acid detection is an emerging bioanalytical method that makes use of the target DNA or RNA strand to initiate a fluorogenic reaction. The Staudinger reduction holds particular promise for templated sensing of nucleic acids because the involved functional groups are highly chemoselective. Here, the azidomethoxy group, which can be removed… CONTINUE READING