7-Azetidinylquinolones as antibacterial agents. Synthesis and structure-activity relationships.


A series of novel antibacterial quinolones and naphthyridones has been prepared which contain 7-azetidinyl substituents in place of the usual piperazine or aminopyrrolidine groups. These azetidinyl derivatives were evaluated for in vitro activity by determining minimum inhibitory concentrations against a variety of bacteria. In vivo efficacy in the mouse… (More)


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@article{Frigola19937AzetidinylquinolonesAA, title={7-Azetidinylquinolones as antibacterial agents. Synthesis and structure-activity relationships.}, author={Jordi Frigola and Jaime Par{\'e}s and Jordi Corbera and David Gutierrez Va{\~n}{\'o} and Ramon Merc{\'e} and Antoni Torrens and Josep Mas and Edoardo Valenti}, journal={Journal of medicinal chemistry}, year={1993}, volume={36 7}, pages={801-10} }