• Corpus ID: 15144886

7 α-Methyl-19-Nortestosterone (MENT): Pharmacokinetics and Antigonadotropic Effects in Men

@inproceedings{Suvisaari20007,
  title={7 $\alpha$-Methyl-19-Nortestosterone (MENT): Pharmacokinetics and Antigonadotropic Effects in Men},
  author={Janne Suvisaari},
  year={2000}
}
................................................................................................................. 9 Introduction .......................................................................................................... 11 Review of the Literature....................................................................................... 13 Overview of Androgen Physiology ............................................................. 13 Synthesis and Secretion of Androgens… 
ethesis.helsinki.fi

References

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Radioimmunoassay of 7α-methyl-19-nortestosterone and investigation of its pharmacokinetics in animals
Steroid 5 alpha-reductase: two genes/two enzymes.
TLDR
The structure of the determinants of apoptosis, a type of cell death, and the role that individual cells play in this process are studied.
7Alpha-methyl-19-nortestosterone maintains sexual behavior and mood in hypogonadal men.
TLDR
It is demonstrated that MENT has similar effects on sexual activity and mood states as testosterone in hypogonadal men, and its development as a potential androgen replacement therapy is supported.
7α-methyl-19-nortestosterone, a synthetic androgen with high potency: structure-activity comparisons with other androgens
In Vitro Metabolism of 7α-Methyl-19-Nortestosterone by Rat Liver, Prostate, and Epididymis
TLDR
The in vitro metabolism of 7α-methyl- 19-nortestosterone was investigated in male rat liver, ventral prostate, and epididymis and it is concluded that the androgenic potency of the steroid is not dependent on its further conversion to 5α-dihydro-metabolites.
Effect of finasteride, a 5 alpha-reductase inhibitor, on serum gonadotropins in normal men.
TLDR
It is concluded that suppression of serum DHT levels with 5 mg finasteride daily in healthy young men has no discernible effect on serum gonadotropin levels.
Aromatization of 7 alpha-methyl-19-nortestosterone by human placental microsomes in vitro.
Part of the biological effects of testosterone (T) are mediated by its enzymatic reduction to 5 alpha-dihydrotestosterone (DHT) or aromatization to estradiol (E2). 7 alpha-Methyl-19-nortestosterone…
Estrogenic and progestational activity of 7α-methyl-19-nortestosterone, a synthetic androgen
In vitro metabolism of 7 alpha-methyl-19-nortestosterone by rat liver, prostate, and epididymis.
TLDR
The androgenic potency of 7-alpha-methyl-19-nortestosterone is not dependent on its further conversion to 5 alpha-dihydro-metabolites, and the kinetics of metabolism in liver differed significantly from those of testosterone or 19-nortsestosterone.
Pharmacokinetics, bioefficacy, and safety of sublingual testosterone cyclodextrin in hypogonadal men: comparison to testosterone enanthate--a clinical research center study.
TLDR
It is concluded that SLT may be a useful addition to the currently available injectable and transdermal delivery systems for treatment of hypogonadal men because of the ease of administration, rapid reversibility of effects, and lower AUC of serum T levels achieved compared to those of TE injections.
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