7,8-dihydroxyflavone rescues spatial memory and synaptic plasticity in cognitively impaired aged rats.

@article{Zeng201278dihydroxyflavoneRS,
  title={7,8-dihydroxyflavone rescues spatial memory and synaptic plasticity in cognitively impaired aged rats.},
  author={Yan Zeng and Feng Lv and Long Li and Hui Yu and Min Dong and Qinghai Fu},
  journal={Journal of neurochemistry},
  year={2012},
  volume={122 4},
  pages={
          800-11
        }
}
7,8-dihydroxyflavone (7,8-DHF) has recently been identified as a potential TrkB agonist that crosses the blood-brain barrier after i.p. administration. We previously demonstrated that 7,8-DHF in vitro rescues long-term synaptic plasticity in the hippocampus of aged rats. This study assessed the rescue effect of 7,8-DHF in vivo on aging-related cognitive impairment in rats, and further determined whether the effect of 7,8-DHF is age dependent. Aged rats at 22 and 30 months of age were pretested… CONTINUE READING

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The prodrug of 7,8-dihydroxyflavone development and therapeutic efficacy for treating Alzheimer's disease.

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