7,8-dihydroxyflavone, a TrkB receptor agonist, blocks long-term spatial memory impairment caused by immobilization stress in rats.

@article{Andero201278dihydroxyflavoneAT,
  title={7,8-dihydroxyflavone, a TrkB receptor agonist, blocks long-term spatial memory impairment caused by immobilization stress in rats.},
  author={Ra{\"u}l Andero and N{\'u}ria Daviu and Rosa Mar{\'i}a Escorihuela and Roser Nadal and Antonio Armario},
  journal={Hippocampus},
  year={2012},
  volume={22 3},
  pages={399-408}
}
Post-traumatic stress disorder (PTSD) patients show cognitive deficits, but it is unclear whether these are a consequence of the pathology or a pre-existing factor of vulnerability to PTSD. Animal models may help to demonstrate whether or not exposure to certain stressors can actually induce long-lasting (LL; days) impairment of hippocampus-dependent memory tasks and to characterize neurobiological mechanisms. Adult male rats were exposed to 2-h immobilization on boards (IMO), a severe stressor… CONTINUE READING

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