7,3'-dimethoxy hesperetin inhibits inflammation by inducing synovial apoptosis in rats with adjuvant-induced arthritis.

@article{Li201373dimethoxyHI,
  title={7,3'-dimethoxy hesperetin inhibits inflammation by inducing synovial apoptosis in rats with adjuvant-induced arthritis.},
  author={Rong Li and Li Cai and Xue-Feng Xie and Lei Peng and Ting-ni Wu and Jun Li},
  journal={Immunopharmacology and immunotoxicology},
  year={2013},
  volume={35 1},
  pages={139-46}
}
Rheumatoid arthritis (RA) is an autoimmune disease characterized by pronounced inflammation and excessive synovial hyperplasia within affected joint. We previously reported 7, 3'-dimethoxy hesperetin (DMHP) as a highly anti-inflammatory active derivative of hesperidin showed apparent pro-apoptotic effect in vitro on fibroblast-like synoviocytes of rats with adjuvant arthritis (AA), an animal model of RA. Here, we investigated the therapeutic effects of DMHP on inflammation and synovial… CONTINUE READING