7,12-Dimethylbenz[a]anthracene--DNA adducts in Sprague-Dawley and Long-Evans female rats: the relationship of DNA adducts to mammary cancer.

@article{Daniel1984712DimethylbenzaanthraceneDNAAI,
  title={7,12-Dimethylbenz[a]anthracene--DNA adducts in Sprague-Dawley and Long-Evans female rats: the relationship of DNA adducts to mammary cancer.},
  author={F. Bernard Daniel and Nola Joyce},
  journal={Carcinogenesis},
  year={1984},
  volume={5 8},
  pages={1021-6}
}
7,12-Dimethylbenz[a]anthracene (DMBA) is a powerful carcinogen to the mammary gland of the pubescent female Sprague-Dawley (S.D.) rat but is a much less potent inducer of mammary adenocarcinoma in the female Long-Evans (L.E.) rat of the same age. The livers of both strains are refractory to DMBA. The maximum levels of DMBA--DNA adducts formed, in both the mammary gland and liver following i.p. administration of [3H]DMBA (21 mumol) were significantly higher (p less than 0.01) in the resistant L… CONTINUE READING