6q deletion discriminates Waldenström macroglobulinemia from IgM monoclonal gammopathy of undetermined significance.

@article{Schop20066qDD,
  title={6q deletion discriminates Waldenstr{\"o}m macroglobulinemia from IgM monoclonal gammopathy of undetermined significance.},
  author={Roelandt F. J. Schop and Scott A Van Wier and Ruifang Xu and Irene Ghobrial and Gregory J. Ahmann and Philip R. Greipp and Robert A Kyle and Angela Dispenzieri and Martha Q. Lacy and S Vincent Rajkumar and Morie A Gertz and Rafael Fonseca},
  journal={Cancer genetics and cytogenetics},
  year={2006},
  volume={169 2},
  pages={150-3}
}
IgM monoclonal gammopathy of undetermined significance (IgM MGUS) and Waldenström macroglobulinemia (WM) are sometimes clinically difficult to distinguish. In our previous study, deletion of the long arm of chromosome 6 (6q) was found in about half of WM patients. To further clarify the area of minimal deletion at 6q (6q-) and to address the issue of whether 6q- occurs in IgM MGUS, 12 IgM MGUS and 38 WM patients were studied by fluorescence in situ hybridization using probes targeting different… CONTINUE READING