6d.01: Obestatin Induces Nitric Oxide-dependent Vasodilation and Inhibits Endothelin-1 Activity in Human Obesity.

@article{Schinzari20156d01OI,
  title={6d.01: Obestatin Induces Nitric Oxide-dependent Vasodilation and Inhibits Endothelin-1 Activity in Human Obesity.},
  author={Francesca Schinzari and Manfredi Tesauro and Alberto Paoluzzi and Nadia Mores and Valentina Rovella and Nicola Di Daniele and Carmine Cardillo},
  journal={Journal of hypertension},
  year={2015},
  volume={33 Suppl 1},
  pages={e82}
}
OBJECTIVE Obese patients have vascular dysfunction related to impaired nitric oxide (NO)-dependent vasodilation and enhanced endothelin (ET)-1 activity. Obestatin is a gastrointestinal peptide with favorable metabolic actions linked to obesity and type 2 diabetes; it has also been shown to exert cardiovascular benefits in experimental models by producing vascular relaxation via specific activation of endothelium-dependent NO signaling. In the present study we tested the hypothesis that… CONTINUE READING