6S RNA regulation of relA alters ppGpp levels in early stationary phase

@inproceedings{Cavanagh20106SRR,
  title={6S RNA regulation of relA alters ppGpp levels in early stationary phase},
  author={Amy T. Cavanagh and Pete Chandrangsu and Karen Montzka Wassarman},
  booktitle={Microbiology},
  year={2010}
}
6S RNA is a small, non-coding RNA that interacts directly with σ(70)-RNA polymerase and regulates transcription at many σ(70)-dependent promoters. Here, we demonstrate that 6S RNA regulates transcription of relA, which encodes a ppGpp synthase. The 6S RNA-dependent regulation of relA expression results in increased ppGpp levels during early stationary phase in cells lacking 6S RNA. These changes in ppGpp levels, although modest, are sufficient to result in altered regulation of transcription… CONTINUE READING
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