6R-Tetrahydrobiopterin induces dopamine synthesis in a human neuroblastoma cell line, LA-N-1. A cellular model of DOPA-responsive dystonia.

Abstract

Dopa-responsive dystonia (DRD) is an extrapyramidal disorder caused by deficit of 5,6,7,8-tetrahydrobiopterin (BH4), cofactor for tyrosine hydroxylase (TH). In these patients the nigrostriatal dopaminergic neurons normally express TH and the cellular machinery for the dopamine uptake. LA-N-1 is a human neuroblastoma cell line expressing tyrosine hydroxylase… (More)

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@article{Zuddas20026RTetrahydrobiopterinID, title={6R-Tetrahydrobiopterin induces dopamine synthesis in a human neuroblastoma cell line, LA-N-1. A cellular model of DOPA-responsive dystonia.}, author={Alessandro Zuddas and Cristina Mancosu and Vanessa Lilliu and Giuseppe Sorrentino and Umberto di Porzio and Carlo Cianchetti}, journal={Brain research}, year={2002}, volume={943 2}, pages={257-62} }