6R-L-erythro-5,6,7,8-tetrahydrobiopterin (R-THBP, SUN 0588) acts on the brain muscarinic and nicotinic cholinergic receptors as evaluated by positron emission tomography (PET) in rhesus monkey.

  title={6R-L-erythro-5,6,7,8-tetrahydrobiopterin (R-THBP, SUN 0588) acts on the brain muscarinic and nicotinic cholinergic receptors as evaluated by positron emission tomography (PET) in rhesus monkey.},
  author={Yoshihiro Tani and Takafumi Ishihara and Tadashi Kanai and Tomochika Ohno and Y. Watanabe and Jesper L. R. Andersson and A Lilija and G{\"o}ran Westerberg and Per Hartvig and Bengt L{\aa}ngstr{\"o}m},
  journal={Advances in experimental medicine and biology},
6R-L-erythro-5,6,7,8-tetrahydrobiopterin (R-THBP) is the natural cofactor for phenylalanine, tyrosine and tryptophan monooxygenases, the latter two enzymes catalyses the rate-limiting reactions in the synthesis of catecholamines and serotonin, respectively. Among various types of pterins, R-THBP has attracted researcher’s interest in recent years, since R-THBP regulates not only the biosynthesis but also the release of biogenic amines such as dopamine and serotonin1,2 and other… Expand
1 Citations
Pteridines and Neuroimmune Function and Pathology
(1997). Pteridines and Neuroimmune Function and Pathology. Journal of Chronic Fatigue Syndrome: Vol. 3, No. 1, pp. 69-86.


A novel action of 6R- l -erythro-5,6,7,8-tetrahydrobiopterin , a cofactor for hydroxylases of phenylalanine, tyrosine and tryptophan: Enhancement of acetylcholine release in vivo in the rat hippocampus
Results show that 6R-BH4 has direct ACh releasing action in vivo, and this action was eliminated after inhibition of voltage-dependent Na+ channels by tetrodotoxin and after depletion of catecholamines by reserpine. Expand
Monoamine-mediated enhancement of acetylcholine release in rat hippocampus by 6R-l-erythro-5, 6, 7, 8-tetrahydrobiopterin
The results show that 6R-BH4 stimulates exocytotic ACh release in the hippocampus through action on a local monoaminergic system in the hippocampal region of rats pretreated with reserpine to deplete monoamines. Expand
6R-tetrahydrobiopterin perfusion enhances dopamine, serotonin, and glutamate outputs in dialysate from rat striatum and frontal cortex
Results suggest that R-THBP may play a role in the mechanisms of release of dopamine, serotonin, and glutamate in urethane-anesthetized rats and the functioning of the catecholaminergic system probably mediates the increase in glutamate output due to R- THBP perfusion. Expand
Enhancement of Dopamine Release In Vivo from the Rat Striatum by Dialytic Perfusion of 6R‐l‐erythro‐5,6,7,8‐Tetrahydrobiopterin
The results suggest that 6R‐BH4 has a dopamine‐releasing action, which is not dependent on biosynthesis of dopamine. Expand
Analysis of reduced forms of biopterin in biological tissues and fluids.
A reverse-phese high-performance liquid chromatography procedure was developed for the separation of biopterin from other unconjugated pteridines and a possible role for tetrahydroneopterin as a cofactor in the enzymatic hydroxylation of aromatic amino acids in man is discussed. Expand
Mapping muscarinic receptors in human and baboon brain using [N‐11C‐methyl]‐benztropine
Data combined with postmortem studies in humans and primates demonstrate that [N‐11C‐methyl]‐benztropine is a suitablemuscarinic cholinergic ligand for use in human and baboon brain and high resolution positron emission tomography (PET). Expand