6R-[3H]tetrahydrobiopterin binding activities in rat brain.

@article{Watanabe19936R3HtetrahydrobiopterinBA,
  title={6R-[3H]tetrahydrobiopterin binding activities in rat brain.},
  author={Y. Watanabe and Hiroshi Morii and Yasuo Nemoto and Bernd Mayer and Ernst R. Werner and Soichi Miwa and Y. Watanabe},
  journal={Advances in experimental medicine and biology},
  year={1993},
  volume={338},
  pages={
          301-4
        }
}
6R-L-Erythro-5,6,7,8-Tetrahydrobiopterin (R-THBP) is a common cofactor for phenylalanine, tyrosine, and tryptophan hydroxylases, the latter two of which are the rate-limiting enzymes of catecholamines and serotonin biosyntheses, respectively. In an attempt to answer the puzzle from the clinical evaluation that R-THBP and L-DOPA or 5-HTP possess the additive effect on the treatment of atypical phenylketonuria, Parkinsonian disease, and infantile autism, we recently found a novel role of R-THBP… Expand
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  • Chemistry, Medicine
  • American journal of physiology. Regulatory, integrative and comparative physiology
  • 1997
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Molecular Mechanisms of Tetrahydrobiopterin Action on Neurotransmitter Release
6R-L-erythro-5,6,7,8-tetrahydrobiopterin (R-THBP) is a common cofactor for phenylalanine, tyrosine, and tryptophan hydroxylases, the latter two of which are the rate-limiting enzymes ofExpand
6R-tetrahydrobiopterin perfusion enhances dopamine, serotonin, and glutamate outputs in dialysate from rat striatum and frontal cortex
TLDR
Results suggest that R-THBP may play a role in the mechanisms of release of dopamine, serotonin, and glutamate in urethane-anesthetized rats and the functioning of the catecholaminergic system probably mediates the increase in glutamate output due to R- THBP perfusion. Expand
Monoamine-mediated enhancement of acetylcholine release in rat hippocampus by 6R-l-erythro-5, 6, 7, 8-tetrahydrobiopterin
TLDR
The results show that 6R-BH4 stimulates exocytotic ACh release in the hippocampus through action on a local monoaminergic system in the hippocampal region of rats pretreated with reserpine to deplete monoamines. Expand
Enhancement of Dopamine Release In Vivo from the Rat Striatum by Dialytic Perfusion of 6R‐l‐erythro‐5,6,7,8‐Tetrahydrobiopterin
TLDR
The results suggest that 6R‐BH4 has a dopamine‐releasing action, which is not dependent on biosynthesis of dopamine. Expand
Solubilization and Characterization of Prostaglandin E2 Binding Protein from Porcine Cerebral Cortex
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Results suggest that a specific protein solubilized may be responsible for the binding site of prostaglandin E2. Expand
Brain nitric oxide synthase is a biopterin‐ and flavin‐containing multi‐functional oxido‐reductase
TLDR
It is found that purified NO synthase contains enzyme‐bound H4 biopterin, explaining the enzymatic activity observed in the absence of added cofactor, and these results indicate that No synthase essentially depends on H4Biopterin as a cofactor which is recycled during enzymatically NO formation. Expand
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TLDR
It is shown that nitric oxide synthetase activity requires calmodulin, and the native enzyme appears to be a monomer. Expand