68Ga-DOTANOC: a first compound for PET imaging with high affinity for somatostatin receptor subtypes 2 and 5

@article{Wild200468GaDOTANOCAF,
  title={68Ga-DOTANOC: a first compound for PET imaging with high affinity for somatostatin receptor subtypes 2 and 5},
  author={Damian Wild and Helmut Robert M{\"a}cke and Beatrice Waser and Jean Claude Reubi and Mihaela Ginj and Helmut Rasch and Jan Mueller-Brand and Michael Hofmann},
  journal={European Journal of Nuclear Medicine and Molecular Imaging},
  year={2004},
  volume={32},
  pages={724}
}
  • Damian Wild, Helmut Robert Mäcke, +5 authors Michael Hofmann
  • Published 2004
  • Medicine
  • European Journal of Nuclear Medicine and Molecular Imaging
  • Existing somatostatin-based radiotracers (e.g. In-DOTA TOC) have sole affinity for somatostatin receptor subtype 2 (sst2). This represents a drawback, given that sst1–5 have been shown to be over-expressed in different tumours, alone or concomitantly [1]. Our goal, therefore, was to develop radiopeptides with broader receptor subtype profiles. Ga-DOTANOC is a first compound for PET imaging with high affinity for sst2 and sst5 [2]. Its affinity profile (IC50 nM) for human sst1–5 is, respectively… CONTINUE READING

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