68Ga-DOTA-NGR as a novel molecular probe for APN-positive tumor imaging using MicroPET.

@article{Zhang201468GaDOTANGRAA,
  title={68Ga-DOTA-NGR as a novel molecular probe for APN-positive tumor imaging using MicroPET.},
  author={Jun Zhang and Xiaoli Lu and Nan Wan and Zi-Chun Hua and Zizheng Wang and Hongbo Huang and Min Yang and Feng Wang},
  journal={Nuclear medicine and biology},
  year={2014},
  volume={41 3},
  pages={268-75}
}
UNLABELLED Aminopeptidase N (APN) is selectively expressed on many tumors and the endothelium of tumor neovasculature, and may serve as a promising target for cancer diagnosis and therapy. Asparagine-glycine-arginine (NGR) peptides have been shown to bind specifically to the APN receptor and have served as vehicles for the delivery of various therapeutic drugs in previous studies. The purpose of this study was to synthesize and evaluate the efficacy of a (68)Ga-labeled NGR peptide as a new… CONTINUE READING
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