64Cu-Labeled Inhibitors of Prostate-Specific Membrane Antigen for PET Imaging of Prostate Cancer

@inproceedings{Banerjee201464CuLabeledIO,
  title={64Cu-Labeled Inhibitors
of Prostate-Specific
Membrane Antigen for PET Imaging of Prostate Cancer},
  author={Sangeeta Ray Banerjee and Mrudula Pullambhatla and Catherine A Foss and Sridhar Nimmagadda and Riccardo Ferdani and Carolyn Jane Anderson and Ronnie C. Mease and Martin G. Pomper},
  booktitle={Journal of medicinal chemistry},
  year={2014}
}
Prostate-specific membrane antigen (PSMA) is a well-recognized target for identification and therapy of a variety of cancers. Here we report five (64)Cu-labeled inhibitors of PSMA, [(64)Cu]3-7, which are based on the lysine-glutamate urea scaffold and utilize a variety of macrocyclic chelators, namely NOTA(3), PCTA(4), Oxo-DO3A(5), CB-TE2A(6), and DOTA(7), in an effort to determine which provides the most suitable pharmacokinetics for in vivo PET imaging. [(64)Cu]3-7 were prepared in high… CONTINUE READING