60S pre-ribosome formation viewed from assembly in the nucleolus until export to the cytoplasm.

@article{Nissan200260SPF,
  title={60S pre-ribosome formation viewed from assembly in the nucleolus until export to the cytoplasm.},
  author={Tracy A Nissan and Jochen Ba\ssler and Elisabeth Petfalski and David Tollervey and Ed Hurt},
  journal={The EMBO journal},
  year={2002},
  volume={21 20},
  pages={5539-47}
}
60S ribosomes undergo initial assembly in the nucleolus before export to the cytoplasm and recent analyses have identified several nucleolar pre-60S particles. To unravel the steps in the pathway of ribosome formation, we have purified the pre-60S ribosomes associated with proteins predicted to act at different stages as the pre-ribosomes transit from the nucleolus through the nucleoplasm and are then exported to the cytoplasm for final maturation. About 50 non-ribosomal proteins are associated… CONTINUE READING
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