60-kDa heat shock protein of Chlamydia pneumoniae promotes a T helper type 1 immune response through IL-12/IL-23 production in monocyte-derived dendritic cells.

@article{Ausiello200660kDaHS,
  title={60-kDa heat shock protein of Chlamydia pneumoniae promotes a T helper type 1 immune response through IL-12/IL-23 production in monocyte-derived dendritic cells.},
  author={Clara Maria Ausiello and Giorgio Fedele and Raffaella Palazzo and Fabiana Spensieri and Alessandra Ciervo and Antonio Cassone},
  journal={Microbes and infection},
  year={2006},
  volume={8 3},
  pages={714-20}
}
Infection, in particular by Chlamydia pneumoniae (Cp), has been associated with atherosclerosis and coronary heart disease. Immune reactions to heat shock proteins (HSPs) have been advocated to link infection to atherosclerosis and its acute sequelae based on molecular mimicry with host HSPs. We have here evaluated the role played by recombinant Cp-HSP60 and Cp-HSP10 for their ability to induce maturation of human monocyte-derived dendritic cells (MDDC) and T cell polarization. Cp-HSP60, but… CONTINUE READING
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