6. Understanding Protein Structure in Water

  title={6. Understanding Protein Structure in Water},
    Most proteins are composed of linear polymers of amino acids. For the 20 common amino acids, nine have apolar sidechains, six have uncharged polar sidechains and hydrogen bonding groups, and five have charged polar sidechains. Two of the latter amino acids are positively charged at pH 7.4 and two are negatively charged at pH 7.4. In the interior of a folded protein, there is little water and most residues form intraprotein hydrogen bonds. As detailed in Section 4, the low dielectric environment… CONTINUE READING