6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase-3 is required for transforming growth factor β1-enhanced invasion of Panc1 cells in vitro.

@article{Yalcin20176phosphofructo2kinasefructose2I,
  title={6-phosphofructo-2-kinase/fructose 2,6-bisphosphatase-3 is required for transforming growth factor $\beta$1-enhanced invasion of Panc1 cells in vitro.},
  author={Abdullah Yalcin and Tugba H Solakoglu and Selahattin C Ozcan and Saime Guzel and Sabire Peker and Serap Çelikler and Başak Balaban and Elif Demirdogen Sevinc and Yunus Gurpinar and Jason Alan Chesney},
  journal={Biochemical and biophysical research communications},
  year={2017},
  volume={484 3},
  pages={
          687-693
        }
}
Transforming growth factor β1 (TGFβ1) is a well-established inducer of the epithelial-mesenchymal transition (EMT) that is essential for the acquisition of malignant properties, such as invasion, in tumor cells. Although recent studies suggest that the EMT in tumor cells is associated with reprogramming of energy metabolism and TGFβ1 has been shown to stimulate glycolysis in multiple primary cell lines, little is known about TGFβ1's effect on glycolysis and glycolytic regulators in transformed… Expand
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ACLY Adenosine triphosphate citrate lyase ALL Acute lymphoblastic leukemia AMPK 5′ AMP-activated protein kinase AT-RvD1 Aspirin-triggered resolvin D1 CAV1 Caveolin-1 CDKs Cyclin-dependent kinases CDP Cytidine 5′-difosfocholine CHKα Choline kinase ChREBP Carbohydrate-responsive element-binding protei
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It is demonstrated that siRNA silencing of endogenous PFKFB3 inhibits Cdk1 activity, which in turn stabilizes p27 protein levels causing cell cycle arrest at G1/S and increased apoptosis in HeLa cells. Expand
Inhibition of 6-phosphofructo-2-kinase (PFKFB3) suppresses glucose metabolism and the growth of HER2+ breast cancer
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It is found that PFKFB4 is required for cancer cell survival during the metabolic response to hypoxia, presumably to enable glycolytic production of ATP when the electron transport chain is not fully operational. Expand
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These findings demonstrate for the first time that the estrogen receptor directly promotes PFKFB3 mRNA transcription which, in turn, is required for the glucose metabolism and survival of breast cancer cells. Expand
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