6-hydrogen-8-methylquinolones active against replicating and non-replicating Mycobacterium tuberculosis.

Abstract

The screening of an in-house quinolones library against Mycobacterium tuberculosis (Mtb) H(37) Rv, followed by a first cycle of optimization, yielded 6-hydrogen-8-methyl derivatives endowed with good potency. The antitubercular activity also encompassed the bacteria in a non-replicating state (NRP-TB) with minimum inhibitory concentration values lower than… (More)
DOI: 10.1111/cbdd.12022

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