6 alpha,7 alpha-cyclopropane derivatives of androst-4-ene: a novel class of competitive aromatase inhibitors.

Abstract

6 alpha,7 alpha-Cyclopropane steroids were found to be potent competitive inhibitors of human placental aromatase. 6 beta,7 beta-Dihydro-3'H-cyclopropa [6,7]-androst-4-en-17-one (4) has extremely high affinity for aromatase (Ki = 5 nM) but does not cause a time-dependent inactivation of the enzyme. 

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Cite this paper

@article{Numazawa19916AA, title={6 alpha,7 alpha-cyclopropane derivatives of androst-4-ene: a novel class of competitive aromatase inhibitors.}, author={Mitsuteru Numazawa and Ayako Mutsumi}, journal={Biochemical and biophysical research communications}, year={1991}, volume={177 1}, pages={401-6} }