6-Thioguanine for Crohn's disease during pregnancy: thiopurine metabolite measurements in both mother and child.

@article{Boer20056ThioguanineFC,
  title={6-Thioguanine for Crohn's disease during pregnancy: thiopurine metabolite measurements in both mother and child.},
  author={Nanne K. H. de Boer and Ruurd M. van Elburg and Abraham J. Wilhelm and Adriana J Remmink and John M. G. van Vugt and Chris Jacob Johan Mulder and A A van Bodegraven},
  journal={Scandinavian journal of gastroenterology},
  year={2005},
  volume={40 11},
  pages={1374-7}
}
6-Thioguanine is used as an escape thiopurine for treating inflammatory bowel disease patients intolerant or refractory to azathioprine, 6-mercaptopurine or methotrexate. Case reports show conflicting data on the use of 6-thioguanine throughout pregnancy. The administration of the standard thiopurines is believed to be relatively safe. We describe two patients with Crohn's disease treated with low-dose 6-thioguanine during all trimesters of their pregnancies. The pregnancies resulted in two… CONTINUE READING
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