6-Phosphate Receptors Cardiomyocytes Bind and Activate Native Human Prorenin : Role of Soluble Mannose

Cardiomyocytes bind, internalize, and activate recombinant human prorenin through mannose 6-phosphate/ insulin-like growth factor II (M6P/IGFII) receptors. To investigate whether this also applies to native human prorenin, neonatal rat myocytes were incubated for 4 hours at 37°C with various prorenin-containing human body fluids. Uptake and activation by… CONTINUE READING