6-OHDA Lesions of the Nucleus Accumbens Accentuate Memory Deficits in Animals with Lesions to the Forebrain Cholinergic Projection System: Effects of Nicotine Administration on Learning and Memory in the Water Maze

@article{Grigoryan19966OHDALO,
  title={6-OHDA Lesions of the Nucleus Accumbens Accentuate Memory Deficits in Animals with Lesions to the Forebrain Cholinergic Projection System: Effects of Nicotine Administration on Learning and Memory in the Water Maze},
  author={G. A. Grigor’yan and Helen Hodges and Sydney B. Mitchell and John D. Sinden and Jeffrey A. Gray},
  journal={Neurobiology of Learning and Memory},
  year={1996},
  volume={65},
  pages={135-153}
}
The separate and combined effects of lesions to the forebrain cholinergic projections system (FCPS) and to dopamine (DA) terminals in the nucleus accumbens (n.acc) were assessed in two water maze tasks: (1) standard acquisition using two trials/day with a 10 min intertrial interval (ITI) for 15 days with the platform in the same position and (2) a working memory task requiring matching to a platform position located by chance on Trial 1, with four trials/day separated by a 30-s ITI and a… CONTINUE READING

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Cognitive effects of nicotine

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  • 2001
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