6-OHDA Induces Oxidation of F-box Protein Fbw7β by Chaperone-Mediated Autophagy in Parkinson’s Model

@article{Wang20176OHDAIO,
  title={6-OHDA Induces Oxidation of F-box Protein Fbw7β by Chaperone-Mediated Autophagy in Parkinson’s Model},
  author={Xiufeng Wang and Heng Zhai and Fang Wang},
  journal={Molecular Neurobiology},
  year={2017},
  volume={55},
  pages={4825-4833}
}
Parkinson’s disease (PD) is the most common movement disorder disease, and its pathological feature is the degenerative loss of dopaminergic neurons in the substantia nigra compacta (SNc). In this study, we investigated whether distinct stress conditions target F-box protein Fbw7β via converging mechanisms. Our results showed that the 6-hyroxydopamine (6-OHDA), which causes PD in animals’ models, led to decreased stability of Fbw7β in DA neuronal SN4741 cells. Further experiments suggested that… CONTINUE READING
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