6-Methylapigenin and hesperidin: new valeriana flavonoids with activity on the CNS

@article{Marder20036MethylapigeninAH,
  title={6-Methylapigenin and hesperidin: new valeriana flavonoids with activity on the CNS},
  author={M. Marder and H. Viola and C. Wasowski and S. Fern{\'a}ndez and A. Paladini},
  journal={Pharmacology Biochemistry and Behavior},
  year={2003},
  volume={75},
  pages={537-545}
}
  • M. Marder, H. Viola, +2 authors A. Paladini
  • Published 2003
  • Medicine, Psychology
  • Pharmacology Biochemistry and Behavior
  • Valerian is an ancient tranquillizing drug obtained from the underground organs of several Valeriana species. Its active principles were assumed to be terpenoids in the form of valepotriates and/or as components of the essential oil. However, unknown active compounds were not discarded and synergic effects were suspected. We have recently isolated 6-methylapigenin (MA) from Valeriana wallichii and proved that it is a benzodiazepine binding site (BDZ-bs) ligand [Planta Med. 68 (2002) 934]. The… CONTINUE READING
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    References

    SHOWING 1-10 OF 26 REFERENCES
    Isolation of pharmacologically active benzodiazepine receptor ligands from Tilia tomentosa (Tiliaceae).
    • 96
    Overview—Flavonoids: A New Family of Benzodiazepine Receptor Ligands
    • 178
    GABA(A)-receptor ligands of flavonoid structure.
    • 161
    The Scientific Basis for the Reputed Activity of Valerian
    • P. Houghton
    • Biology, Medicine
    • The Journal of pharmacy and pharmacology
    • 1999
    • 350
    The effects of triazolobenzodiazepines in two animal tests of anxiety and in the holeboard
    • 147