6-Methyl-3'-bromoflavone, a high-affinity ligand for the benzodiazepine binding site of the GABA(A) receptor with some antagonistic properties.

@article{Viola19996Methyl3bromoflavoneAH,
  title={6-Methyl-3'-bromoflavone, a high-affinity ligand for the benzodiazepine binding site of the GABA(A) receptor with some antagonistic properties.},
  author={H. Viola and M. Marder and J. Nunez and L. Izquierdo and C. Wasowski and C. Wolfman and P. Ardenghi and D. Barros and J. Medina and A. Paladini},
  journal={Biochemical and biophysical research communications},
  year={1999},
  volume={262 3},
  pages={
          643-6
        }
}
  • H. Viola, M. Marder, +7 authors A. Paladini
  • Published 1999
  • Biology, Medicine
  • Biochemical and biophysical research communications
  • 6-Methyl-3'-bromoflavone inhibited [(3)H]flunitrazepam binding to the benzodiazepine binding site of the GABA(A) receptor (BDZ-bs) with Ki values between 10 and 50 nM in different brain regions. The GABA ratio of 1.03 for [(3)H]flunitrazepam binding to cerebral cortex, 0.76 for cerebellum, 0.7 for hippocampus, 0.7 for striatum, and 0.8 for spinal cord indicated an antagonistic or weak inverse agonistic profile of 6-methyl-3'-bromoflavone on BDZ-bs. Unlike classical benzodiazepines, it had no… CONTINUE READING
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