6-Hydroxylation: An important metabolic route for α-methyltryptamine

  title={6-Hydroxylation: An important metabolic route for $\alpha$-methyltryptamine},
  author={St. Sz{\'a}ra},
  • S. Szára
  • Published 15 February 1961
  • Biology
  • Experientia
Der Stoffwechsel der psychotropischen Verbindung α-Methyltryptamin wurde untersucht. Die drei hauptsächlichsten Metabolite wurdenin vitro undin vivo als 6-Hydroxy-α-methyltryptamin, 3-Indolylaceton und 6-Hydroxy-3-indolylaceton identifiziert. 

Behavioral effects of α,α,β,β-tetradeutero-5-MeO-DMT in rats: comparison with 5-MeO-DMT administered in combination with a monoamine oxidase inhibitor

Deuterated tryptamines may be useful in behavioral and pharmacological studies to mimic the effects of tryptamine/MAOI combinations to indicate that the hyperactivity induced by 5- MeO-DMT after MAO inhibition is a consequence of reduced metabolism of 5-MeO- DMT, leading to prolonged occupation of central serotonin receptors.

Studies on the metabolism of the new anti-hypertensive agent, indoramin, in man

The absorption, metabolism and excretion of the new antihypertensive agent indoramin (Baratol®) have been studied in male volunteers following oral administration of the drug labelled either with 14C or with tritium, with pattern of biotransformation similar to that in the patas monkey.

Chemistry and Structure-Activity Relationships of Psychedelics.

  • D. Nichols
  • Biology
    Current topics in behavioral neurosciences
  • 2018
This chapter will summarize structure-activity relationships (SAR) that are known for the classic serotonergic hallucinogens (aka psychedelics), focusing on the three chemical types: tryptamines,

A general screening and confirmation approach to the analysis of designer tryptamines and phenethylamines in blood and urine using GC-EI-MS and HPLC-electrospray-MS.

A screening method based on gas chromatography-mass spectrometry was developed and successfully applied to blood and urine samples in suspected AMT intoxications, detecting metabolites reported previously as 5-methoxy-N,N-diisopropyltryptamine-N'-oxide and 5-MeO-DiPT-N-oxide.

Effects of psychotropic drugs on open-field behaviour in rats

Three stimulant and 5 depressant drugs were tested but no consistent pattern of activity emerged and the only drug which caused decrease in emotional defaecation, thiopropazate, also caused concurrent decrease in all other measured categories of behaviour.



Hydroxylation and N-demethylation of N,N-dimethyltryptamine

An weiteren Stoffwechselprodukten wurden nachgewiesen: N,N-Dimethyltryptamin-N-oxyd und sein 6-Hydroxy-Derivat (in vitro), sowie Tryptamin, Indol-3-essigsäure und 6-hydroxyindol- 3-essigäure (in vivo).

The enzymatic deamination of amphetamine (benzedrine).

  • J. Axelrod
  • Biology, Chemistry
    The Journal of biological chemistry
  • 1955